This book provides a comprehensive overview of the development of metabolic syndrome, the underlying mechanisms and therapeutic strategies for drug development. The authors examine the context of underlying molecular pathways and integrated physiology, then expanding the discussion to diseases associated with metabolic syndrome. The development of drug therapies for these diseases and complications is extensively covered. The book offers a comprehensive and in-depth view of energy metabolism, metabolic tissues and pathways, molecular mechanism-based drug discovery and clinical implications.
Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids provides current research exploring the links among insulin, insulin receptors, polyunsaturated fatty acids, brain growth and disease. Specific interactions of essential fatty acids and polyunsaturated fatty acids in brain development and several disease groups are described. The role of inflammation in disease and how fatty acids regulate low-systemic inflammation are examined and explained. Metabolic and neurologic dynamics are presented to provide a linkage between the presence of omega-3 and omega-6 and protection against diseases and conditions such as diabetes mellitus, obesity, autoimmune diseases and hypertension.
The relationship of metabolic diseases to cardiovascular disease (CVD) is reaching epidemic proportions. This relates mostly to the increasing prevalence of obesity, the metabolic syndrome and type 2 diabetes. This book outlines and addresses the metabolic factors and related diseases that contribute to CVD, including brief introductions to metabolic pathways including lipid and lipoprotein metabolism, macronutrient fuel partitioning, insulin action and body weight regulation. Mechanisms that relate to becoming obese, maintenance of the obese state, the dyslipidemias, and glucose intolerance/diabetes are also addressed, and the importance of interventions that reduce metabolic risk factors and CVD are covered.
Practical advice and information for living with Polycystic Ovarian Syndrome Polycystic Ovary Syndrome (PCOS) is a condition in which there is an imbalance of a woman's female sex hormones, and affects an estimated 10% of all women. This hormone imbalance may cause changes in the menstrual cycle, acne, small cysts in the ovaries, difficulty conceiving, high blood pressure, and other problems. It is treatable, but not curable, and sufferers have to rely on themselves for the long-term management of their condition. If you're living with PCOS, this guide gives you the latest information concerning treatments and research into Polycystic Ovarian Syndrome. PCOS For Dummies gives you a practical, plain-English guide to living with and managing Polycystic Ovarian Syndrome. In addition to providing valuable information concerning the causes and symptoms of Polycystic Ovarian Syndrome, PCOS For Dummies gives you the facts about the various treatment options that are available, including both traditional medical treatments and alternative therapies. Discusses the causes and symptoms of PCOS Advice for dealing with this disorder Covers the treatments and medicine available in the United States PCOS For Dummies is an invaluable resource for the millions who are suffering from this condition.
In Why Nonprofits Fail, author and nonprofit expert Stephen Block explains that many well-intentioned leaders hold on to views of their nonprofit organizations that perpetuate problems rather than help fix them. According to Block, the first step to success is to challenge one's own personal paradigms and ideas and be open to unique and alternative approaches to solving problems. This much-needed book helps nonprofits get back on track and offers advice about the seven most common stumbling blocks, including: Founder's syndrome Fundphobia Financial misfortune Recruitment disorientation Cultural depression in nonprofit organizations Self-serving political performance Role confusion between the board and executive director
Asperger's Syndrome For Dummies covers everything that both people living with the condition and their families need to know. From explaining symptoms and getting a diagnosis, through to overcoming bullying in schools and choosing between the therapy and medical treatments available, this is a complete guide to surviving and thriving with the condition. Asperger's Syndrome For Dummies includes: Part I: Understanding Asperger's syndrome (AS) Chapter 1: Introducing Asperger's syndrome Chapter 2: Discovering the causes of Asperger's syndrome Chapter 3: Diagnosing Asperger's syndrome Part II: Living with Asperger's syndrome Chapter 4: Enjoying Life with Asperger's Chapter 5: Getting the most out of education and the workplace Chapter 6: Finding independence and advocating for your rights Part III: Supporting people with Asperger's syndrome Chapter 7: Parenting and Asperger's syndrome Chapter 8: Relating to adults with Asperger's syndrome Chapter 9: Creating an AS friendly environment Part IV: Discovering therapies, medication, diet and environments for AS Chapter 10: Navigating Behavioural Therapies for Asperger's Syndrome Chapter 11: Understanding medication and diet in Asperger's syndrome Part V: Part of Tens Chapter 12: Ten Organisations to go for help and information Chapter 13: Ten positives about living with Asperger's Chapter 14: Ten famous people who probably had Asperger's
Up-to-date, reliable information about Tourette Syndrome and related disorders for teachers and parents Children with TS are often teased and punished for the unusual yet uncontrollable symptoms of their disorder. Academic failure is common. The Tourette Syndrome/OCD Checklist helps parents and teachers to better understand children and youth with TS and/or OCD and provide the support and interventions these children need. Presented in a simple, concise, easy-to-read checklist format, the book is packed with the latest research, practical advice, and information on a wide range of topics. Provides a wealth of information on Tourette Syndrome, Obsessive-Compulsive Disorder, and related conditions Includes strategies for discipline and behavior management, advice on supporting and motivating kids with TS and OCD, homework tips, and more Shows how to educate peer students about TS and OCD Loaded with practical information, strategies, and resources, this book helps parents and teachers to better understand Tourette Syndrome and OCD and shows how every individual can reach their potential in school and in life.
Beverly Engel brings her expertise to this important examination of the Jekyll and Hyde Syndrome—the first book to address this abusive syndrome. She discusses the origins of the disorder, names its seven major manifestations, explains how to identify Jekyll and Hyde behavior in other people and in oneself, and outlines clear steps for how to heal Jekyll and Hyde tendencies for good.
An incisive look at the consequences of today's costly and damaging suburban lifestyle In The Cul-de-Sac Syndrome, Bloomberg News' John Wasik exposes the economic, cultural, environmental, and health problems underlying life in suburbia. Wasik provides powerful insights into how the U.S. suburban lifestyle has become unsustainable and what can be done to salvage it. His observations are firmly grounded in exclusive on-the-ground research, interviews with thought leaders, and the latest studies and statistics. The book Exposes the untold truths about suburban home ownership: green isn't always so green, life isn't cheaper after accounting for gas, water, and taxes, and modern suburban living isn't so idyllic considering the toll it takes on our health Includes exclusive research and analysis by experts in the field that debunks the many myths associated with suburban living Explores innovative solutions being developed in cities across the country The American Dream of moving further from a city to buy a bigger house and find better schools has become a costly nightmare. The Cul-de-Sac Syndrome examines why and what can be done.
Praise for Doing Therapy with Children and Adolescents with Asperger Syndrome «Providing an explanation of Asperger's based on a review of scientific research, Richard Bromfield describes how the characteristics of the syndrome affect the person's thoughts and experiences throughout childhood. Psychotherapy based on the practices described in this book will change the destiny of children and adults with Asperger Syndrome to one of greater connectivity to themselves and others. This should become the primary text for pshchotherapists working with children and adolescents with Asperger's.» —Tony Attwood, PhD, author of The Complete Guide to Asperger's Syndrome «Dr. Blomfield generously shares his wisdom and experience in this very accessible, honest, and often moving book. Any clinician who reads it in its entirely—or even selects a chapter or two at random—will no doubt discover new paths to take their most complex and challenging clients and gain a greater appreciation for those with Asperger Syndrome. Bromfield gives us all a window into a world that is hard to describe, impossible to imagine, but needs and deserves to be understood.» —Naomi Angoff Chedd, LMHC, Autism Specialist and coauthor of Replays Cutting-edge guidance for effective treatment of children and adolescents with Asperger Syndrome Diagnoses of Asperger Syndrome in children and adolescents are on the rise, and while some clinicians have training and experience in this area, most do not. Using vivid case material, Doing Therapy with Children and Adolescent with Asperger Syndrome offers clinicians the guidance they need to treat the young people they endeavor to help.
An insightful guide to making strategic investment allocation decisions that embraces both alternative and conventional assets In this much-needed resource, alternative and portfolio management expert John Abbink demonstrates new ways of analyzing and deploying alternative assets and explains the practical application of these techniques. Alternative Assets and Strategic Allocation clearly shows how alternative investments fit into portfolios and the role they play in an investment allocation that includes traditional investments as well. This book also describes innovative methods for valuation as applied to alternatives that previously have been difficult to analyze. Offers institutional investors, analysts, researchers, portfolio managers, and financial academics a down-to-earth method for measuring and analyzing alternative assets Reviews some of the latest alternatives that are increasing in popularity, such as high-frequency trading, direct lending, and long-term investment in real assets Outlines a strategic approach for including alternative investments into portfolios and shows the pivotal role they play in an investment allocation Using the information found in this book, you'll have a clearer sense of how to approach investment issues related to alternative assets and discover what it takes to make these products work for you.
A comprehensive guide to alternative investments that reveals today's latest research and strategies Historically low interest rates and bear markets in world stock markets have generated intense interest in alternative investments. With returns in traditional investment vehicles relatively low, many professional investors view alternative investments as a means of meeting their return objectives. Alternative Investments: Instruments, Performance, Benchmarks, and Strategies, can put you in a better position to achieve this difficult goal. Part of the Robert W. Kolb Series in Finance, Alternative Investments provides an in-depth discussion of the historic performance, benchmarks, and strategies of every major alternative investment market. With contributions from professionals and academics around the world, it offers valuable insights on the latest trends, research, and thinking in each major area. Empirical evidence about each type of alternative investment is featured, with research presented in a straightforward manner. Examines a variety of major alternative asset classes, from real estate, private equity, and commodities to managed futures, hedge funds, and distressed securities Provides detailed insights on the latest research and strategies, and offers a thorough explanation of historical performance, benchmarks, and other critical information Blends knowledge from the conceptual world of scholars with the pragmatic view of practitioners in this field Alternative investments provide a means of diversification, risk control, and return enhancement and, as such, are attractive to many professional investors. If you're looking for an effective way to hone your skills in this dynamic area of finance, look no further than this book.