This comprehensive text integrates related aspects of wound management, skin integrity and dermatology into a convenient, one-stop resource. It explores the theories underpinning wound management and skin integrity by reviewing the supporting evidence and making practical recommendations for busy clinicians. Wound Healing and Skin Integrity discusses current and future trends in the management of wounds and maintenance of skin integrity in respect to international healthcare initiatives and summarises the principles of maintaining healthy skin to provide a practical guide that is accessible to clinicians regardless of professional background. The title fulfils the inter-professional learning agenda and will be of interest to a wide range of clinicians, including doctors; wound management, dermatology and palliative care nurse specialists; community nurses; podiatrists; pharmacists; and anyone responsible for managing patients with impaired skin integrity. Key features: A practical, accessible, evidence-based manual on wound care and skin integrity Integrates related aspects of skin integrity, wound management and dermatology previously found in separate texts into one comprehensive resource Written from a broad international perspective with contributions from key international opinion leaders from Australia, UK, Canada and Europe Promotes international practice development in relation to management of skin integrity and chronic wounds Full colour illustrations throughout Defines key terms, relates anatomy and physiology to clinical practice and provides a summary of easily accessible online learning resources Includes practical tips from expert practitioners, commonly presented clinical queries and discussion of professional issues related to skin integrity
The first thorough review of cyclooxygenase inhibitors, including their toxicity mechanisms and toxicopathological risks Cyclooxygenases (COXs) are enzymes responsible for the formation of an important class of biological mediators called prostanoids. Prostanoids such as prostaglandins mediate inflammatory and anaphylactic reactions. For those suffering from inflammation and pain, the pharmacological inhibition of COXs, with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can provide relief. Yet the use of NSAIDs can trigger toxicological effects as well, leading to potential health risks. Comparative Pathophysiology and Toxicology of Cyclooxygenases provides a comprehensive overview of how COX inhibitors affect various bodily systems, specifically the toxicity mechanisms triggered when the COX enzyme is inhibited. The book provides an introduction to the discovery of cyclooxygenases, their use as therapeutic agents, as well as an historical perspective. Shedding light on the differences in expression, pathophysiology, and toxicology of COX inhibitors across species, the book offers a systematic examination of the effects and pathophysiology of COX inhibitors and their mechanisms of toxicity, beginning with the GI tract. Subsequent chapters cover: The pathophysiology of COX inhibition on bone, tendon, and ligament healing COX inhibitors and renal system pathophysiology and mechanisms of toxicity The pathophysiologic role of COX inhibition in the ocular system COX inhibition and the respiratory and cardiovascular systems The book also sheds light on the latest research devoted to developing COX inhibitors with no adverse side-effects. The first book to offer a thorough comparative look at the toxicological effects of COX inhibitors throughout the body, this invaluable resource will help advance the research and development of safer and more effective COX drugs.
The Care of Wounds addresses all aspects of holistic wound management. The fourth edition of this successful clinical text continues to reflect current research and evidence-based practice, while incorporating the considerable developments which have occurred in wound care practice since the previous edition. It includes chapters on the physiology of wound healing, general principles of wound management, wound management products, and the management of patients with both acute and chronic wounds. The title is an essential read for all nurses and healthcare professionals working in the field of tissue viability and wound healing. Comprehensive and clinically-oriented Examines best practice in wound management Incorporates national and international clinical guidelines where applicable Superbly illustrated with full colour throughout
The textbook for students, studying the basic course of pathophysiology in English, is organized according to the module principle and contains summary of lectures on the specific module's topic, tests, clinico-pathophysiological and clinico-laboratory cases for training and control of knowledge, algorithms of solution of the typical problems, and also questions to prepare for classes, colloquia and final examination on pathophysiology. The edition contains the discussions of the subject matter of pathophysiology; its aims, issues, methods, and constituent parts. It summarizes the main concepts of general nosology, etiology and pathogenesis. In a concise format or in a form of schemes, it considers the causes, mechanisms of development, adaptive reactions, manifestations and outcome of the typical pathologic processes and typical forms of pathology of organs and physiological systems, including separate syndromes and nosologic units. Each topic of the pathophysiology course is supplied by a set of clinical case problems, tests for self-control by students, algorithms of solutions of the selected problems, and correct answers for the tests. This textbook is prepared for students and teachers of the English-speaking Division of the Department of Pathophysiology. 3-е издание, переработанное и дополненное.
Self-healing is a well-known phenomenon in nature: a broken bone merges after some time and if skin is damaged, the wound will stop bleeding and heals again. This concept can be mimicked in order to create polymeric materials with the ability to regenerate after they have suffered degradation or wear. Already realized applications are used in aerospace engineering, and current research in this fascinating field shows how different self-healing mechanisms proven successful by nature can be adapted to produce even more versatile materials. The book combines the knowledge of an international panel of experts in the field and provides the reader with chemical and physical concepts for self-healing polymers, including aspects of biomimetic processes of healing in nature. It shows how to design self-healing polymers and explains the dynamics in these systems. Different self-healing concepts such as encapsulated systems and supramolecular systems are detailed. Chapters on analysis and friction detection in self-healing polymers and on applications round off the book.