This is a cross sectional study on 400 cases of diabetes mellitus who attended the National Diabetic centre/ AL–Mustensyria university for a period of 6 months. The main factor of metabolic syndrome was dysglycaemia followed by hypertension, obesity and dyslipidaemia. Females in this study were more prone to have metabolic syndrome; Male: Female ratio = 0.5. Those in the age group 60-69 have the highest frequency of metabolic syndrome. Those with BMI 30-40 have the highest frequency of metabolic syndrome. Conclusion: This study concludes that early diagnosis and aggressive treatment is needed for metabolic syndrome to avoid cardiovascular complications. This study is important because of its predictive power for cardiovascular complication and diabetes.
The metabolic syndrome a concurrence of disturbed glucose and insulin metabolism, overweight and abdominal fat distribution, dyslipidemia and hypertension, is associated with subsequent development of type 2 diabetes mellitus and cardiovascular disease (CVD). Despite its high prevalence in Asians, no national estimate is currently available on the metabolic syndrome in patients with acute myocardial infarction in Pakistan.A matched case control study using questionnaire and analysis of components of metabolic syndrome was carried out at tertiary care hospitals of Peshawar Pakhtunkhwa.The result showed that patients were 6.19 times more likely to have three or more diagnostic criteria of metabolic syndrome than the controls i.e. 55% vs 17%. This study contributed to the fact that metabolic syndrome is more common in patients with acute myocardial infarction. Screening of adults with central obesity for other parameters of the metabolic syndrome may help to reduce the prevalence of metabolic syndrome as well of myocardial infarction at an early age, which is the complication of metabolic syndrome.
The book is intended for a wide range of readers - endocrinologists, cardiologists, neurologists, gynecologists, psychiatrists, psychologists, dieticians, general practitioners, medical students, specializing doctors and patients with obesity, metabolic syndrome, type 2 diabetes mellitus. The monography contains data of the author’s research on neurotrophines, mast cells, chronic inflammatory and psychoemotional distress, changes in salivary glands and thyroidea, chormonal disbalance in metabolic syndrome. By revealing little-known scientific facts about NGF and etiopathogenetic mechanisms of development of cardio-metabolic disease, this book provides an answer to the ways of successful treatment of the abovementioned socially significant diseases.
With respect to considerable lifestyle changes in humans it is expected that there will be change in diseases pattern also. This book gives a comprehensive approach to readers to understand basic concept of metabolic syndrome.This book is being primarily designed for new researchers. It also gives an ideas to researchers to carry out studies of metabolic syndrome in rural areas. This study also reveals the necessity of various health schemes to be launched in rural areas and traditional communities for health for all. The style of text is simple and lucid. References are given at the end of each chapter.It will definitely be immense help as a source of excellent information to all readers with easy understanding.
Metabolic Syndrome refers to the clustering of risk factors including obesity, elevated blood pressure (hypertension), elevated blood sugars, dyslipidaemia (high triglycerides & low HDL concentration) and hence increased risk for developing many serious medical conditions including type 2 diabetes, myocardial infarction, and stroke & early death. Lifestyle changes, one of the main factor, due to fast increasing urbanization, especially in developing countries like India, has led to the development of serious health problems like obesity, hypertension, diabetes, etc. which in turn lead to the complications like Metabolic Syndrome . About one third of the urban population in India’s major cities have Metabolic Syndrome. The National Cholesterol Education Program Adult Treatment Panel III simplified the definition of Metabolic Syndrome to make it user friendly for medical practitioners. Our study included faculty members of different professional streams using NCEP ATPIII criteria and was concluded that medical faculty had maximum percentage of subjects having Metabolic Syndrome. Early lifestyle modification leads to the reduction in these risk factors and hence to Metabolic Syndrome.
" Are psoriasis and metabolic syndrome offshoots of the same root?" is a small exercise to make a scientific understanding of etiological association of the two processes. Although a good beginning, still lot of research is needed in this field. C-reactive protein, a marker of inflammation, can be used to sort out those psoriatic patients who are likely to benefit from therapy by biological agents and can also help to delineate those psoriatic patients who are at high risk of developing a metabolic syndrome.
The metabolic syndrome is a complex cardiometabolic cluster characterized by hyperinsulinaemia, low glucose tolerance, dyslipidaemia, hypertension and obesity. It represents a significant marker of increased risk for both cardiovascular disease and type 2 diabetes. To fight efficiently the forecasted type 2 diabetes and its cardiovascular and metabolic complications, evidence-based strategies, focusing on target groups at risk, are needed to tailor prevention programs. In this context, the overall aim of this work was to investigate, for the first time, the epidemiological profile of the metabolic syndrome, its variations and its potential socioeconomic, behavioral and biological determinants among the adult population residing in Luxembourg. Such data should offer new possibilities for successful intervention to prevent and treat the metabolic syndrome before the coronary heart disease and type 2 diabetes develop in susceptible individuals and groups.
Metabolic syndrome is a modern era disease which has engulfed wide regions of the world and the problem is increasing at a rapid pace. The atherogenic dyslipidemia associated with the metabolic syndrome predispose to cardiovascular events. The Statins are considered first-line therapy for treating Dyslipidemia. Clinical response to statins is highly variable and genetic factors play an important role. Sterol regulatory element binding factors (SREBF) – SREBF Cleavage Activating Protein (SCAP) pathway play important roles in lipid metabolism and homeostasis. Identification of genes & genetic variants that influence statin responsiveness holds promise for a safe and effective treatment of Dyslipidemia in Metabolic syndrome.
The present study was performed to study the metabolic syndrome indicators in male cigarette smokers. The study was conducted on 100 male subjects. Demographic measurements such as height, weight, blood pressure, pulse, history of diabetes or any other major disease were taken of all the subjects. Blood samples were collected and blood serum was separated and run into chemistry analyzer. Analysis of variance (ANOVA) was applied on the parameters for the comparison of mean between three groups. The mean cholesterol level in non-smokers was 176.56±4.10 mg/dl while in light smokers and heavy smokers was 169.65±6.31 mg/dl and 180.65±4.70 mg/dl respectively, mean triglyceride level in non-smokers was 170.76±3.15 while in light and heavy smokers was 151.17±5.71 mg/dl and 173.42±7.79 mg/dl respectively. The mean HDL level in non-smokers was 44.0±0.34 mg/dl while in light and heavy smokers was 40.45±0.83 mg/dl and 40.85±0.65 mg/dl, mean value of LDL level in non-smokers was 98.50±3.96 mg/dl while in light and heavy smokers was 98.91±6.11 mg/dl and 105.08±4.61 mg/dl respectively. As the lipid profile was high in heavy smokers and they were at a higher risk of developing metabolic syndrome.
Nurses who are mostly shift workers were found to be at risk for coronary heart disease (CHD). A cross sectional study was conducted among 404 female nurses working in a teaching hospital in Kelantan, Malaysia to determine the prevalence of metabolic syndrome and its associated factors. Data were collected using a proforma consisted of sociodemographic data, occupational history, physical activity and DASS 42 questionnaire (validated Malay version). Anthropometric, blood pressure measurement and fasting venous blood were taken from each subject for fasting lipid profile and blood sugar. The prevalence of metabolic syndrome was 24.3% (95% CI: 20.1, 28.4). The significant factors associated with metabolic syndrome were total duration of employment (years) and one way commuting time to work (minutes). High prevalence of metabolic syndrome indicates that nurses are occupational high risk group for CHD. Occupational factors which significantly associated with metabolic syndrome in this study are total duration of employment and one way commuting time to work, however there is no significant relationship between metabolic syndrome and shift work as well as self-perceived job stress.
This publication is devoted to the pressing problems of metabolic syndrome and their scrutiny. Data presented includes fresh information on classification and diagnostics of glucose homeostasis abnormalities, physiology and pathophysiology of glucose metabolism and lipid exchange. The treatment of metabolic syndrome manifestations has become a critical issue. The book includes findings on etiology and pathogenesis of the syndrome and introduces up-to-date treatment methods. A separate chapter presents material on hypolipidemic therapy in the course of the syndrome. The book is intended for the use in professional education, further training of general practitioners and by students of medical schools.
Focusing on the exciting field of research covers the mechanisms and molecules that involved in the pathogenesis of the metabolic syndrome . Specific topics include the changing areas of interest, such as fetal growth, oxidative stress, inflammation and adipocytokines, and also including vascular complications, atherothrombosis, genetics had been inserted. Over the past few years there has been an exponential increase in interest the Metabolic Syndrome best described perhaps as a clustering of closely related cardiovascular disease (CVD) risk factors. Since the original ‘description’ of the metabolic syndrome, the ‘hypertension- hyperglycaemia-hyperuricaemia syndrome’, early in the last century by a Swedish physician, Eskil Kylin, it has been recognised that concurrent CHD and type 2 diabetes often occur in overweight patients. Reaven linked resistance to insulin-stimulated glucose uptake, with increased blood pressure, glucose concentrations and dyslipidaemia. Undoubtedly much will be learned over the next few years about the aetiology. There will be a search for new drugs which can treat several of the components of the syndrome.
Metabolic syndrome is an abnormal accumulation of the pathological state of a variety of metabolic components and many complex obstacles. In recent years, the increasing incidence has caused great concern in the international medical field. Scientists are actively exploring new drugs to combat this affliction. This book details descriptions, the current situation and research methods of metabolic syndrome and type 2 diabetes, with particular emphasis on herbal extracts and anti-RBP4 RNA oligonucleotide prevention and intervention. This book also covers studies of Chinese herbal extract treatment and prevention of non-alcoholic fatty liver disease and Alzheimer's disease. By reading this book, readers can share in the stimulating data and valuable scientific information, and garner influential experience about this topic.
Metabolic Syndrome is an aggregation of conditions that together increases the risk of cardiovascular disease in individuals that would not otherwise be recognized to be at risk. Aim: to assess the status of high sensitive C reactive protein (hs-CRP) in patients with Metabolic Syndrome. METHODS: This study is a cross-sectional study. The patients included in this study were 48 patients (of both sexes) attending the Diabetic Consultant Clinic during the period from January, 2010 till the end of September, 2010. The study included another 50 apparently healthy volunteer that were comparable to patients group with respect to age and sex and serve as a control group. They were screened for Metabolic Syndrome criteria.For the two groups hs-CRP was measured using ELISA kit. The results: BMI and BP were significantly higher in the MetS than the control. MetS group had significantly higher (hs-CRP) levels than control group and significantly higher Lipid profile than the control group. In conclusion, high sensitive C Reactive Protein can thus be simple, powerful markers of Metabolic Syndrome.
Metabolic syndrome in India is starting up, so this initiative is taken to study the prevalence among college students.Its a original work and a novel project funded by state government.The definitions, classes are clearly taken care. Studies among college students in India is very rare so this project is been pursued and have seen the prevalence of metabolic Syndrome in India is between 10 - 20% among the college goers and especially among girls.