Diabetes mellitus is a complex metabolic disease associated with peripheral and central complications. These complications include retinopathy, nephropathy and neuropathy. Several investigations have confirmed the role of oxidative stress in developmental diabetic mediated disorders, possibly via the formation of free radicals . Chronic antioxidant therapies may be useful in decreasing the risk of diabetic complications, from these antioxidants coenzyme Q10 which acts as an antioxidant, inhibiting lipid peroxidation and scavenging free radicals. This study aimed to investigate the brain oxidative stress induced by STZ in rats with consequent changes in brain neurotransmitters and examined the potential protective role of coenzyme Q10 (CoQ10) against the changes STZ induced. Our results cleared that coenzyme Q 10 seems to be a highly promising compound in protecting the diabetic rats against oxidative damage and preventing brain complications such as elevation of neurotransmitters.
Coauthors: Dr. Jitendra D. Vaghasiya (Ph.D.), Associate Professor of Pharmacology is actively engaged in teaching, research and service to his profession and Ms. Dipal Patel, a Young Researcher obtained her M.Pharm degree in Pharmacology in 2012. A study was designed to investigate Coenzyme Q10 treatment on scopolamine induced memory loss using Morris water maze test and passive avoidance test followed by estimation of Malondialdehyde (MDA), reduced glutathione (GSH), Nitric oxide (NO) and glutamate levels in mice. Coenzyme Q10 showed significant memory enhancing effect in mice that was indicated by significant increase in escape latency time in passive avoidance model and decrease in escape latency time in Morris water maze test at 50 & 100 mg/kg dose levels. Treatment with same doses of Coenzyme Q10 in mice showed decrease in MDA, Glutamate and NO levels and increase in GSH levels in brain tissue homogenates. This suggest that the antioxidant activity of the drug may prevent the oxidative neuronal damage in brain and therefore may be responsible for the anti-amnesic effect of Coenzyme Q10.
Организм человека - это сложная структура, работа которой складывается из нормального функционирования всех органов. Стрессы, экология и возраст оказывают отрицательное влияние на здоровье и могут стать причинами сбоев в работе различных частей организма. Компания Geneticlab nutrition создала продукт Coenzyme Q10, который содержит Коэнзим Q10 (99%) и лецитин из масла подсолнечника - два кита безупречного здоровья и противостояния возрастным изменениям.
Coenzyme Q10 plays a pivotal role in mitochondrial respiratory chain for cell power supply. Coenzyme Q10 serves as a physiological electron (e–) shuttle from complexes I and II to complex III, as well as a potent antioxidant. In different types of neurological disorders, dysfunction of the respiratory chain leads to reduced ATP levels and increased generation of reactive oxygen species. Coenzyme Q10 supplementation has been widely used in such targeted therapies, including aging, stroke, neuromuscular diseases, Parkinson’s disease, Alzheimer's disease, progressive supranuclear palsy, autosomal recessive cerebellar ataxias, amyotrophic lateral sclerosis and Huntington’s disease. This book summarized a large number of experimental and clinical trials for Coenzyme Q10 based therapies in Neurology.