Death as a phenomenon has always baffled mankind. No one wants to die yet every moment we are dying. In fact the medical science has proven that every cell in the human body degenerates and there is a constant regeneration. This degeneration or decay is nothing but death. In fact death as a phenomenon scares us because we have the limited understanding of life. Death is an absolutely necessary process for life to be. It is not the enemy, it is the friend. And it is not there somewhere in the future, it is here, now. It is not going to happen, it has been always happening. With each exhalation it happens -- a little death, a small death -- but because of fear we have put it in the future.The mind always tries to avoid things which it cannot comprehend, and death is one of the most incomprehensible mysteries. The following pages is the authors understanding of death which is a constant companion of a practicing physician as well as his readings about what the great philosophers and religion has commented on this intriguing topic.The topics are a part of collection of lectures taken by theprincipal author during his discourses on the topic of understanding death.
This manuscript is an autoethnographic study in which the author explores her struggles with death anxiety throughout her life. In order to gain a deeper understanding of her experiences, the author connects her personal narrative to scholarly data on death anxiety, bereavement, cancer diagnosis and recovery, and “wounded healers.” The author offers a detailed account of her experiences with death including the death of her grandfather as a child, her own thyroid cancer diagnosis as a young adult, and how her diagnosis interacted with her fears of death post-recovery. Within this book, the author seeks to comprehend how her fears of death, cancer diagnosis, and recovery will influence her work as a therapist. By offering her personal narrative, the author’s aim is to be a companion to others who endure similar struggles with death anxiety or an illness and to help others gain a deeper understanding of what it feels like to live through death anxiety and a cancer diagnosis. This book will be a resource for counsellors, psychologists, doctors, and other healthcare professionals, as well as others who wish to support someone who experiences death anxiety or a life-threatening illness.
Breast cancer is the most common type of cancer among females, both in incidence and death. As meaningful biological understanding of the disease is confounded by the existence of various molecular groups and sub-groups, the challenge for targeted drug development may lie in understanding the molecular mechanisms of various sub-groups in breast cancer. This book describes the gene expression profiling approach for deeper understanding of the dynamics of breast cancer progression and prognosis.
Hepatocellular carcinoma is one of the leading cancer-related causes of death. So far, no life-saving therapy is available, due to a widespread resistance of cancer cells to apoptosis, impeding effectual treatment with anticancer drugs. Thus, an improved understanding of apoptosis and other cell death pathways is fundamental to develop new drugs to bypass tumor drug resistance. This study characterizes caspase-independent apoptosis induced by the death receptor-ligand CD95L in HepG2 cells. Furthermore the role of cyclophilin A (CypA) and apoptosis inducing factor (AIF) in apoptotic cell death are studied. An essential role of CypA in apoptotic cell death is demonstrated. On the one hand this protein is essential for the activation of at least effector caspases and on the other hand, the outcome of cell death is modulated both upon overexpression and knockdown of CypA.
Most children will experience the death of a loved one in their lifetime and will need to develop healthy grieving patterns. Communication between parents and children is a key ingredient in facilitating this development. Current opinions about bibliotherapy, using a book to assist in healing, suggest that books provide understanding about grief and death and open channels of communication. Although the use of bibliotherapy is gaining popularity, little research exists about its efficacy. Utilizing the book The Bridge to Terabithia, this study evaluated the facilitation of communication about death between 19 dyads of mother and adolescent sons. Their answers and comments illustrate the effectiveness of bibliotherapy in opening channels of communication about death. The results of this study support the efficacy of bibliotherapy.
Mitochondria are vital cell organelles which sustain cellular life by acting as energy factories in a normal cell. Under certain circumstances, mitochondria turn into the gateways to death by releasing death-inducing proteins into the cytosol. The channels in the mitochondrial outer membrane that allow the efflux of the death-inducing proteins from mitochondria into the cytosol are unknown. My graduate research work was focused on understanding the nature of these channels both structurally and functionally. I discovered that the lipid called ceramide and the protein called Bax act together to facilitate protein release from mitochondria. My work shed further insights into how ceramide forms channels. I also explored the dynamics of channel formation by Bax. I developed ionic strength as a useful diagnostic tool study Bax channel formation in vitro.